The use of proteins involved in the photosynthetic process enables the development of affordable and efficient devices for energy conversion. However, although proteins such as photosystem I are robust in nature, the use of isolated protein complexes incorporated in semi-artificial electrodes is associated with a considerably short long-term stability. Thus, technological application is still limited. Researchers showed that careful operation of the photosystem-based bioelectrode under the exclusion of oxygen is the key for achieving high stability.