Preterm infants with respiratory distress syndrome (RDS) face heightened risks of death, critical illness, and prolonged hospitalization, particularly if they progress to develop acute respiratory distress syndrome (ARDS). A new study suggests that treatment with nasal high-frequency oscillatory ventilation (NHFOV) is a beneficial management strategy in this population, and is superior to nasal continuous positive airway pressure (NCPAP) in preventing reintubation.