Researchers have found a new common thread linking nearly all of the trinucleotide repeat expansion diseases, which include ALS, Huntington's Disease and Fragile X Syndrome, involving the complicated 3D patterns that the DNA is folded into in order to fit in the nucleus of the cell. Nearly all of the short tandem repeats known to grow unstable in disease are located at the boundaries that separate neighboring folded domains.
Class of neurological disorders share 3D genome folding pattern
Researchers have found a new common thread linking nearly all of the trinucleotide repeat expansion diseases, which include ALS, Huntington's Disease and Fragile X Syndrome, involving the complic..
