Candidiasis is a painful infection that affects a large number of individuals, occasionally causing severe pain that is solely controlled by resolution of infection. Here, Dectin-1 inhibition was found to block pain during fungal infection. Researchers found that clodronate, a drug that is currently used for osteoporosis treatment, could suppress severe pain in fungal infection, and that the Dectin-1 pathway could be an important new target for treatment of pain.