A study has uncovered a brain-signaling pathway that can be pharmacologically manipulated in mice to reverse an autism-related pathway. Using an experimental drug targeting this pathway, researchers normalized the disrupted physiology and behavior of these mice. Moreover, effects were seen in adult mice, suggesting a possible route to developing medications for adults with autism spectrum disorder. Remarkably, the study also showed physiological changes linked to gut function in the mice, a medical comorbidity of ASD.